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Androgen Receptor Gene Mutations DB
Full Name of the Resource : Mutations in the androgen receptor gene
Resource Category : Databases -> Human Genes and Diseases -> Gene-System or Disease-Specific Databases

  1. Title of the Paper : The Androgen Receptor Gene Mutations Database (View at PubMed)
    Contributors : Gottlieb, B.; Lehvaslaiho, H.; Beitel, L. K.; Lumbroso, R.; Pinsky, L.; Trifiro, M.
    Address : Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Chemin de la Cote-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada. mc33@musica.mcgill.ca
    Publication Name : Nucleic Acids Res
    Volume : 26
    Issue : 1
    Pages : 234-8
    Publication Year : 1998
    ISSN : 0305-1048 (Print) 0305-1048 (Linking)
    Language : English
    Abstract : The current version of the androgen receptor (AR) gene mutations database is described. The total number of reported mutations has risen from 272 to 309 in the past year. We have expanded the database: (i) by giving each entry an accession number; (ii) by adding information on the length of polymorphic polyglutamine (polyGln) and polyglycine (polyGly) tracts in exon 1; (iii) by adding information on large gene deletions; (iv) by providing a direct link with a completely searchable database (courtesy EMBL-European Bioinformatics Institute). The addition of the exon 1 polymorphisms is discussed in light of their possible relevance as markers for predisposition to prostate or breast cancer. The database is also available on the internet (http://www.mcgill. ca/androgendb/ ), from EMBL-European Bioinformatics Institute (ftp. ebi.ac.uk/pub/databases/androgen ), or as a Macintosh FilemakerPro or Word file (MC33@musica.mcgill.ca).