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  1. tmRNA Website (View Publication)
    Full Name of the Resource : tmRNA sequences and alignments
    Resource Category : Databases -> RNA -> RNA Sequence, Structure and Functions

    Brief Description : tmRNA (also known as 10Sa RNA or SsrA) plays a central role in an unusual process termed trans-translation, whereby a stalled ribosome switches from a problematic mRNA to a short reading frame within tmRNA during translation of a single polypeptide. Research on the mechanism, structure and biology of tmRNA is served by the tmRNA Website, a collection of sequences, secondary structures and other information. Four pseudoknots are usually present in each tmRNA, so the database is rich with information on pseudoknot variability. An interesting variation on tmRNA structure is the two-piece form that results from circular permutation of the gene, which has evolved independently in two separate bacterial lineages. Ongoing genome sequencing projects are diligently monitored, and the database is updated frequently throughout the year.
    Subject Area : tmRNA; mRNA


    Institute/s :
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, USA.
    Address of Institute/s :
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, USA.
    Country : United States

    Associated Institutes :

    • Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, Altos de Pipe, MI, Venezuela
    • Department of Biology, Indiana University, Bloomington, IN 47405, USA

    Associated Country : Venezuela; USA


    Authors/Contributors : Kelly P. Williams
    Contact Email : kellwill@indiana.edu
    Year : 2004
    Language : English

    Keywords : Base Sequence; Computer Communication Networks; Databases, Factual; Nucleic Acid Conformation; RNA, Bacterial; RNA, Messenger; RNA, Transfer