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  1. tmRDB (View Publication)
    Full Name of the Resource : tmRNA database
    Resource Category : Databases -> RNA -> RNA Sequence, Structure and Functions

    Brief Description : tmRNA is a molecule that combines functions of tRNA and mRNA in a process called trans-translation, to rescue ribosomes that are stalled at the end of broken mRNA. tmRNA-like sequences have been identified in all bacteria analyzed to date including mitochondria, chloroplasts, and cyanelles. Recently, tmRNA-like molecules have been discovered also in certain bacteriphages. To assist in the study of structure and function of tmRNA, the tmRNA database (tmRDB) lists the known tmRNA sequences ordered alphabetically and phylogenetically with links to the primary sources. The tmRNA alignment, available in various formats, is the basis for supported tmRNA secondary structures. Three-dimensional models in pdb format generated by ERNA-3D help to investigate potential interactions between the tmRNA and its cofactors. Aligned sequences of tmRNA-encoded tag-peptides which serve as signals for cellular proteases, are included. The tmRDB also provides relevant information about the proteins known to interact with tmRNA such as SmpB, ribosomal protein S1, alanyl-tRNA synthetase, and elongation factor Tu,. The tmRDB is maintained at the University of Texas Health Science Center at Tyler, Texas, and accessible on the World Wide Web at the URL http://psyche.uthct.edu/dbs/tmRDB/tmRDB.html. Mirror sites are located at Auburn University, Auburn, Alabama (http://www.ag.auburn.edu/mirror/tmRDB/) and the Institute of Biological Sciences, Aarhus, Denmark (http://www.bioinf.au.dk/tmRDB/).
    Subject Area : tmRNA; mRNA


    Institute/s :
    Department of Molecular Biology, The University of Texas Health Science Center at Tyler, USA.
    Address of Institute/s :
    Department of Molecular Biology, The University of Texas Health Science Center at Tyler, USA.
    Country : United States

    Associated Institutes :

    • Department of Animal and Dairy Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, AL 36849-5415, U.S.A.
    • Department of Molecular Biology, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
    • Division of Genetics, The Royal Veterinary and Agricultural University, Institute of Animal Science and Animal Health, Groennegaardsvej 3, DK-1870 Frederiksberg C, Denmark
    • Bioinformatics Research Center, University of Aarhus, H¿egh Guldbergsgade 10, DK-8000 Aarhus C, Denmark
    • Department of Medical Biochemistry, Goteborg University Box 440, SE-405 30 Goteborg, Sweden

    Associated Country : USA; Denmark; Sweden


    Authors/Contributors : Zwieb, C
    Contact Email : zwieb@uthct.edu
    Year : 2004
    Language : English

    Keywords : Computer Communication Networks; *Databases, Factual; Information Storage and Retrieval; RNA, Bacterial; RNA, Messenger; RNA, Transfer