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  1. UniGene
    Full Name of the Resource : Unified clusters of ESTs and full-length mRNA sequences
    Resource Category : Databases -> Human and Other Vertebrate Genomes -> Human Proteins

    Brief Description : Expressed sequence tag (EST) analysis is being applied to a growing number of organisms. UniGene provides an organized view of these transcribed sequences by collapsing them into groups that correspond to genes and then connecting these entries to other classes of information that may shed light on gene expression and function. Traditionally, this grouping has been based on all-against-all sequence alignment among the transcript sequences. For the few organisms for which a genomic sequence is available, improved results have recently been obtained by using the genome as a scaffold for grouping transcripts. By taking genomic position into account, it is possible to bring together gene fragments with very short overlaps and to separate near-identical gene family members that might have been inappropriately merged. Tools provided on the UniGene web site allow researchers to browse cDNA libraries by developmental stage or tissue of origin, view surrogate expression profiles based on EST counts, and find groups of genes with similar expression patterns.

    Institute/s :
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Country : United States

    Associated Institutes :

    • National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA

    Associated Country : USA


    Authors/Contributors : David L. Wheeler; Deanna M. Church; Ron Edgar; Scott Federhen; Wolfgang Helmberg; Thomas L. Madden; Joan U. Pontius; Gregory D. Schuler; Lynn M. Schriml; Edwin Sequeira; Tugba O. Suzek; Tatiana A. Tatusova; Lukas Wagner
    Contact Email : wheeler@ncbi.nlm.nih.gov
    Year : 2003
    Language : English