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  1. The HIV Positive Selection Mutation Database
    Resource Category : Databases -> Genomics Databases (non-vertebrate) -> Viral genome databases

    Brief Description : The HIV positive selection mutation database is a large-scale database available at http://www.bioinformatics.ucla.edu/HIV/ that provides detailed selection pressure maps of HIV protease and reverse transcriptase, both of which are molecular targets of antiretroviral therapy. This database makes available for the first time a very large HIV sequence dataset (sequences from approximately 50,000 clinical AIDS samples, generously contributed by Specialty Laboratories Inc.), which makes possible high-resolution selection pressure mapping. It provides information about not only the selection pressure on individual sites, but also how selection pressure at one site is affected by mutations on other sites. It also includes datasets from other public databases, namely the Stanford HIV database (1). Comparison between these datasets in the database enables cross-validation with independent datasets and also specific evaluation of the effect of drug treatment.

    Institute/s :
    University of California Los Angeles, CA, USA
    Address of Institute/s :
    University of California Los Angeles, CA, USA
    State : California
    Country : USA

    Associated Institutes :

    • Center for Computational Biology, University of California Los Angeles, CA, USA
    • Molecular Biology Institute, Institute for Genomics and Proteomics, University of California Los Angeles, CA, USA
    • Department of Chemistry and Biochemistry, University of California Los Angeles, CA, USA

    Associated Country : USA


    Authors/Contributors : Calvin Pan; Joseph Kim; Lamei Chen; Qi Wang; Christopher Lee
    Contact Email : leec@chem.ucla.edu
    Year : 2006
    Language : English