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  1. The Chromosome 7 Annotation Project
    Full Name of the Resource : Human chromosome 7 sequence and annotation
    Resource Category : Databases -> Human and Other Vertebrate Genomes -> Model Organisms, Comparative Genomics

    Brief Description : The objective of this project is to generate the most comprehensive description of human chromosome 7 to facilitate biological discovery, disease gene research and medical genetic applications. The DNA sequence assembly, which encompasses 158,329,839 nucleotides (nt) of DNA, represents the most complete description of this chromosome available. It was generated utilizing Celera whole genome shotgun information, cloned-based sequence from Genbank, and targeted sequence from The Centre for Applied Genomics (TCAG). In comparison to the first version release (Science, 2003) an additional 376,050 nt is present and 23 additional gaps have been filled. This assembly (named CRA_TCAGchr7v2), amongst other variations, contains 704,297 nt of verified sequence not found in NCBI's Build 34 of chromosome 7. To fulfill the objective of having every biological and medically relevant feature annotated along the sequence assembly, all annotation records have been updated and new ones added. For example, the CRA_TCAGchr7v2 assembly displays information from the most current RefSeq, Ensembl, Celera published, UCSC, TIGR Human Gene Index, dbEST and mRNA datasets. Unique TCAG annotations have also been added including a new 'experimentally-confirmed' gene track, all known structural features, as well as 619 new clinical cases of defined phenotype. A new proprietary segmental duplication browser has also been developed for the chromosome 7 browser.

    Institute/s :
    Program in Genetics and Genomic Biology,
    Address of Institute/s :
    Program in Genetics and Genomic Biology, The Hospital for Sick Children, 555 University Ave, Toronto ON M5G 1X8 Canada
    Country : Canada


    Authors/Contributors : MacDonald J.R.; Cheung J.; Zhang J.; Khaja R.; Duggan G.; Kanematsu E.; Scherer S.W.
    Contact Email : jeffm@genet.sickkids.on.ca
    Year : 2003