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  1. TMFunction
    Full Name of the Resource : Functional residues in membrane proteins Database
    Resource Category : Databases -> Protein Sequence Databases -> Protein sequence motifs and active sites

    Brief Description : TMFunction is a database, which is a collection of more than 2900 experimentally observed functional residues in membrane proteins. Each entry includes the numerical values for the parameters IC50 (measure of the effectiveness of a compound in inhibiting biological function), Vmax (maximal velocity of transport), relative activity of mutants with respect to wild type protein, binding affinity, dissociation constant, etc., which are important for understanding the sequence-structure-function relationship of membrane proteins. In addition, we have provided information about the name and source of the protein, Uniprot and Protein Data Bank codes, mutational and literature information. Furthermore, TMFunction is linked to related databases and other resources. We have set up a web interface with different search and display options so that users have the ability to get the data in several ways. TMFunction is freely available.
    Subject Area : Functional Protein Residue


    Institute/s :
    Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Japan.
    Address of Institute/s :
    Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
    Country : Japan

    Associated Institutes :

    • Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.

    Associated Country : Japan


    Authors/Contributors : Gromiha, M.M.
    Contact Email : michael-gromiha@aist.go.jp
    Year : 2009
    Language : English

    Keywords : Amino Acids/chemistry; Databases, Protein; Internet; Membrane Proteins / chemistry / genetics / metabolism; Mutation