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  1. PHI-base (View Publication)
    Full Name of the Resource : Genes affecting fungal pathogen-host interactions
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Other fungi

    Brief Description : To utilise effectively the growing number of verified genes that mediate an organisms ability to cause disease and / or to trigger host responses, we have developed PHI-base. This is a web-accessible database that currently catalogues 405 experimentally verified pathogenicity, virulence and effector genes from 54 fungal and Oomycete pathogens, of which 176 are from animal pathogens, 227 from plant pathogens and 3 from pathogens with a fungal host. PHI-base is the first on-line resource devoted to the identification and presentation of information on fungal and Oomycete pathogenicity genes and their host interactions. As such, PHI-base is a valuable resource for the discovery of candidate targets in medically and agronomically important fungal and Oomycete pathogens for intervention with synthetic chemistries and natural products. Each entry in PHI-base is curated by domain experts and supported by strong experimental evidence (gene / transcript disruption experiments) as well as literature references in which the experiments are described. Each gene in PHI-base is presented with its nucleotide and deduced amino acid sequence as well as a detailed description of predicted proteins function during the host infection process. To facilitate data interoperability, we have annotated genes using controlled vocabularies (Gene Ontology terms, EC Numbers, etc.), and provide links to other external data sources (for example, NCBI taxonomy and EMBL). We welcome new data for inclusion in PHI-base, which is freely accessed at: www4.rothamsted.bbsrc.ac.uk/phibase/.

    Institute/s :
    Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, AL5 2JQ, UK
    Address of Institute/s :
    Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, AL5 2JQ, UK
    Country : United Kingdom

    Associated Institutes :

    • Department of Biomathematics and Bioinformatics, Rothamsted Research, Harpenden, AL5 2JQ, UK
    • Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, AL5 2JQ, UK
    • Institute of Zoology, Johannes Gutenberg-University, Becherweg 9-11, D-55099 Mainz, Germany
    • Department of Plant Pathology, Plant Science Building, Cornell University, Ithaca, NY 14853, USA
    • Protein Research Group, Department of Molecular Biotechnology, Institute of Medical Biology, Faculty of Medicine, University of Tromso, N-9037 Tromso, Norway

    Associated Country : United Kingdom; USA; Norway; Germany


    Authors/Contributors : Rainer Winnenburg; Martin Urban; Andrew Beacham; Thomas K. Baldwin; Sabrina Holland; Magdalen Lindeberg; Hilde Hansen; Christopher Rawlings; Kim E. Hammond-Kosack; Jacob Kohler
    Contact Email : phi-base@bbsrc.ac.uk
    Year : 2008

    Keywords : Anti-Infective Agents / pharmacology; Bacteria / genetics / *pathogenicity; *Databases, Genetic; Fungi / genetics / *pathogenicity; Genes, Bacterial; Genes, Fungal; Host-Pathogen Interactions / *genetics; Internet; Oomycetes / genetics / *pathogenicity; User-Computer Interface; Virulence Factors / antagonists & inhibitors / *genetics