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  1. NOPdb: (View Publication)
    Full Name of the Resource : Nucleolar proteome database
    Resource Category : Databases -> Protein Sequence Databases -> Protein Localization and Targeting

    Brief Description : The Nucleolar Proteome Database (NOPdb) archives data on more than 700 proteins that were identified by multiple mass spectrometry (MS) analyses from highly purified preparations of human nucleoli, the most prominent nuclear organelle. Each protein entry is annotated with information about its corresponding gene, its domain structures and relevant protein homologues across species, as well as documenting its MS identification history including all the peptides sequenced by tandem MS / MS. Moreover, data showing the quantitative changes in the relative levels of ~500 nucleolar proteins are compared at different timepoints upon transcriptional inhibition. Correlating changes in protein abundance at multiple timepoints, highlighted by visualization means in the NOPdb, provides clues regarding the potential interactions and relationships between nucleolar proteins and thereby suggests putative functions for factors within the 30% of the proteome which comprises novel / uncharacterized proteins. The NOPdb (http: / / www.lamondlab.com / NOPdb) is searchable by either gene names, protein sequences, Gene Ontology terms or motifs, or by limiting the range for isoelectric points and / or molecular weights and links to other databases (e.g. LocusLink, OMIM and PubMed).
    Subject Area : Nucleolar Proteome


    Institute/s :
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
    Address of Institute/s :
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Country : United States

    Associated Institutes :

    • Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • Division of Gene Regulation and Expression, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee Dundee DD1 5EH, UK
    • Department of Biochemistry and Molecular Biology, University of Southern Denmark Campusvej 55, DK-5230 Odense M, Denmark

    Associated Country : USA; United Kingdom; Denmark


    Contact Email : akleung@mit.edu
    Year : 2006
    Language : English

    Keywords : Cell Nucleolus / chemistry; Databases, Protein; Humans; Internet; Mass Spectrometry; Nuclear Proteins / chemistry; Peptides / chemistry; Proteome / chemistry