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  1. NLSdb (View Publication)
    Full Name of the Resource : Nuclear localization signals
    Resource Category : Databases -> Protein Sequence Databases -> Protein Localization and Targeting

    Brief Description : NLSdb is a database of nuclear localization signals (NLSs)and of nuclear proteins.NLSs are short stretches of residues mediating transport of nuclear proteins into the nucleus.The database contains 114 experimentally determined NLSs that were obtained through extensive literature search.Using in silico mutagenesis this set was extended to 308 experimental and potential NLSs.This final set matched over 43%of all known nuclear proteins and matches no currently known non-nuclear protein.NLSdb contains over 6000 predicted nuclear proteins and their targeting signals from the PDB and SWISS-PROT databases.The database also contains over 12500 predicted nuclear proteins from six entirely sequenced eukaryotic proteomes (Homo sapiens,Mus musculus,Drosophila melanogaster,Caenorhabditis elegans , Arabidopsis thaliana,and Saccharomyces cerevisiae ).NLS motifs often co-localise with DNA-binding regions.This observation was used to also annotate over 1500 DNA-binding proteins.NLSdb can be accessed via the web site:http: / / cubic.bioc.columbia.edu / db / NLSdb / .
    Subject Area : Nuclear Localization Signal


    Institute/s :
    CUBIC,Department of Biochemistry and Molecular Biophysics, Columbia University, New York, USA
    Address of Institute/s :
    CUBIC,DEp of Biochemistry and molecular biophysics, Columbia University, 630W,168th street, New York,NY 10032
    Country : United States

    Associated Institutes :

    • CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, BB217, 650 West 168th Street, New York, NY 10032, USA
    • Department of Physics, Columbia University, 538 West 120th Street, New York, NY 10027, USA
    • Columbia University Center for Computational Biology and Bioinformatics (C2B2), Russ Berrie Pavilion, 1150 St Nicholas Avenue, New York, NY 10032, USA
    • North East Structural Genomics Consortium (NESG), Department of Biochemistry and Molecular Biophysics, Columbia University, BB217, 650 West 168th Street, New York, NY 10032, USA

    Associated Country : USA


    Authors/Contributors : Rajesh Nair
    Contact Email : nair@cubic.bioc.columbia.edu
    Year : 2003
    Language : English

    Keywords : Active Transport, Cell Nucleus; Animals; Databases, Protein; Humans; Mice; Nuclear Localization Signals; Nuclear Proteins / Chemistry / Metabolism; Proteome / Chemistry