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  1. NESbase (View Publication)
    Full Name of the Resource : Nuclear export signals database
    Resource Category : Databases -> Protein Sequence Databases -> Protein Localization and Targeting

    Brief Description : Protein export from the nucleus is often mediated by a Leucine-rich nuclear export signal (NES) consisting of 4-5 hydrophobic residues within a region of approximately 10 amino acids. Many Leucine-rich NESs have been identified and reported in literature, but until now this information has not been compiled. NESbase is a database of experimentally validated Leucine-rich Nuclear Export Signals (NES) curated from literature. These signals are not annotated in databases such as SWISS-PROT, PIR or PROSITE. Each entry contains information of whether the NES was shown to be necessary and / or sufficient for export, and whether the export was shown to be mediated by the export receptor CRM1. Version 1.0 of NESbase contains 75 entries with 80 experimentally determined NESs. The database is available online at http: / / www.cbs.dtu.dk / databases / NESbase /
    Subject Area : Nuclear Export Signal


    Institute/s :
    Center for Biological Sequence Analysis, Technical University of Denmark, Denmark
    Address of Institute/s :
    Center for Biological Sequence Analysis, Bldg. 208, Technical University of Denmark, DK-288 Lyngby, Denmark
    Country : Denmark

    Associated Institutes :

    • Center for Biological Sequence Analysis, Bldg. 208, Technical University of Denmark, DK-288 Lyngby, Denmark
    • Department of Protein Chemistry, Institute of Molecular Biology, University of Copenhagen, DK-1353 Copenhagen, Denmark

    Associated Country : Denmark


    Authors/Contributors : Tanja la Cour
    Contact Email : brunak@cbs.dtu.dk,tanja@cbs.dtu.dk
    Year : 2003
    Language : English

    Keywords : Active Transport, Cell Nucleus; Amino Acid Motifs; Animals; Conserved Sequence; Databases, Protein; Leucine / chemistry; Proteins / chemistry / metabolism; Sequence Alignment