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  1. NATsDB (View Publication)
    Full Name of the Resource : Natural Antisense Transcripts database
    Resource Category : Databases -> RNA -> RNA Sequence, Structure and Functions

    Brief Description : Natural antisense transcripts (NATs) are reverse complementary at least in part to the sequences of other endogenous sense transcripts. Most NATs are transcribed from opposite strands of their sense partners. They regulate sense genes at multiple levels and are implicated in various diseases. Using an improved whole-genome computational pipeline, we identified abundant cis-encoded exon-overlapping sense-antisense (SA) gene pairs in human, mouse, fly, and eight other eukaryotic species. We developed NATsDB (Natural Antisense Transcripts DataBase, http://natsdb.cbi.pku.edu.cn/) to enable efficient browsing, searching and downloading of this currently most comprehensive collection of SA genes, grouped into six classes based on their overlapping patterns. NATsDB also includes Non-exon-Overlapping Bidirectional (NOB) genes and Non-BiDirectional (NBD) genes. To facilitate the study of functions, regulations, and possible pathological implications, NATsDB includes extensive information about gene structures, polyA signals and tails, phastCons conservation, homologues in other species, repeat elements, EST expression profiles, and OMIM disease association. NATsDB supports interactive graphical display of the alignment of all supporting EST and mRNA transcripts of the SA and NOB genes to the genomic loci. It supports advanced search by species, gene name, sequence accession number, chromosome location, coding potential, OMIM association, and sequence similarity.
    Subject Area : Natural antisense transcripts


    Institute/s :
    Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University Beijing, China.
    Address of Institute/s :
    Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University Beijing 100871, PR China.
    Country : China

    Associated Institutes :

    • Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University Beijing 100871, PR China
    • Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Department of Health and Human Services (DHHS) Box 5180, Baltimore, MD 21224, USA

    Associated Country : China; USA


    Authors/Contributors : Liping Wei
    Contact Email : weilp@mail.cbi.pku.edu.cn
    Year : 2006
    Language : English

    Keywords : Animals; Base Sequence; Databases, Nucleic Acid; Dogs; Genes; Humans; Internet; Mice; Molecular Sequence Data; RNA, Antisense / chemistry / genetics / metabolism; RNA, Messenger / chemistry; Rats; User-Computer Interface