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  1. MulPSSM (View Publication)
    Full Name of the Resource : Multiple PSSMs of structural and sequence families
    Resource Category : Databases -> Protein Sequence Databases -> Protein Domain Databases (Protein Classification)

    Brief Description : Representation of multiple sequence alignments of protein families in terms of Position Specific Scoring Matrices (PSSMs) is commonly used in the detection of remote homologues. A PSSM is generated with respect to one of the sequences involved in the multiple sequence alignment as a reference. We have shown recently that use of multiple PSSMs corresponding to an alignment, with several sequences in the family used as reference, improves the sensitivity of the remote homology detection dramatically [1,2]. MulPSSM contains PSSMs for a large number of sequence and structural families of protein domains with multiple PSSMs for every family [3]. The approach involves use of a clustering algorithm to identify most distinct sequences corresponding to a family. With each one of the distinct sequences as reference, multiple PSSMs have been generated.
    Subject Area : Position Scoring Metrices


    Institute/s :
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    Address of Institute/s :
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    Country : India

    Associated Institutes :

    • Molecular Biophysics Unit, Indian Institute of Science Bangalore 560012, India
    • National Centre for Biological Sciences GKVK Campus, Bangalore 560065, India

    Associated Country : India


    Authors/Contributors : Srinivasan, N.
    Contact Email : ns@mbu.iisc.ernet.in
    Year : 2006
    Language : English

    Keywords : Databases, Protein; Internet; Protein Structure, Tertiary; Sequence Alignment / methods; Sequence Analysis, Protein / methods; User-Computer Interface