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  1. Mpact
    Full Name of the Resource : Yeast protein-protein interaction data
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Fungal Genome Gatabases

    Brief Description : Munich Information Center for Protein Sequences
    Subject Area : In recent years, the Munich Information Center for Protein Sequences (MIPS) yeast protein-protein interaction (PPI) dataset has been used in numerous analyses of protein networks and has been called a gold standard because of its quality and comprehensiveness[ H. Yu, N.M.Luscombe, H. X. Lu, X. Zhu, Y. Xia, J. D. Han, N. Bertin, S. Chung, M. Vidal and M. Gerstein (2004) Genome Res., 14, 1107-1118]. MPact and the yeast protein localization catalog provide information relatedto the proximity of proteins in yeast. Besidethe integration of high-throughput data, information about experimental evidence for PPIs in the literature was compiled by experts adding up to 4300 distinct PPIs connecting 1500 proteins in yeast. As the interaction data is a complementary part of CYGD, interactive mapping of data on other integrated data types such as the functional classification catalog [A. Ruepp, A. Zollner, D. Maier, K. Albermann, J. Hani, M. Mokrejs, I. Tetko, U. Guldener, G. Mannhaupt, M. Munsterkotter and H. W. Mewes (2004) Nucleic Acids Res., 32, 5539-5545] is possible. A survey of signaling proteins and comparison with pathway data from KEGG demonstrates that based on these manually annotated data only anextensive overview of the complexity of this functional network can be obtained in yeast. The implementation of a web-based PPI-analysis tool allows analysis and visualization of protein interaction networks and facilitates integration of our curated data with high-throughput datasets. The complete dataset as well as user-defined sub-networks can be retrieved easily in the standardized PSI-MI format. The resource can be accessed through http://mips.gsf.de/genre/proj/mpact.


    Institute/s :
    Institute for Bioinformatics, GSF National Research Center for Environment and Health, Germany.
    Address of Institute/s :
    Institute for Bioinformatics, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D-85764 Neuherberg, Germany.
    Country : Germany


    Authors/Contributors : Gueldener U.
    Contact Email : u.gueldener@gsf.de
    Year : 2006
    Language : English

    Keywords : *Databases, Protein; Internet; *Protein Interaction Mapping; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/*metabolism; Signal Transduction; Software; Two-Hybrid System Techniques; User-Computer Interface



  2. Mpact
    Full Name of the Resource : Yeast protein-protein interaction data
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Yeasts

    Brief Description : In recent years, the Munich Information Center for Protein Sequences (MIPS) yeast protein-protein interaction (PPI) dataset has been used in numerous analyses of protein networks and has been called a gold standard because of its quality and comprehensiveness[ H. Yu, N.M.Luscombe, H. X. Lu, X. Zhu, Y. Xia, J. D. Han, N. Bertin, S. Chung, M. Vidal and M. Gerstein (2004) Genome Res., 14, 1107-1118]. MPact and the yeast protein localization catalog provide information relatedto the proximity of proteins in yeast. Besidethe integration of high-throughput data, information about experimental evidence for PPIs in the literature was compiled by experts adding up to 4300 distinct PPIs connecting 1500 proteins in yeast. As the interaction data is a complementary part of CYGD, interactive mapping of data on other integrated data types such as the functional classification catalog [A. Ruepp, A. Zollner, D. Maier, K. Albermann, J. Hani, M. Mokrejs, I. Tetko, U. Guldener, G. Mannhaupt, M. Munsterkotter and H. W. Mewes (2004) Nucleic Acids Res., 32, 5539-5545] is possible. A survey of signaling proteins and comparison with pathway data from KEGG demonstrates that based on these manually annotated data only anextensive overview of the complexity of this functional network can be obtained in yeast. The implementation of a web-based PPI-analysis tool allows analysis and visualization of protein interaction networks and facilitates integration of our curated data with high-throughput datasets. The complete dataset as well as user-defined sub-networks can be retrieved easily in the standardized PSI-MI format. The resource can be accessed through http://mips.gsf.de/genre/proj/mpact.
    Subject Area : Protein-Protein Interaction


    Institute/s :
    Institute for Bioinformatics, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany
    Technische Universitaet Muenchen, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science, D-85350 Freising-Weihenstephan, Germany

    Country : Germany

    Associated Institutes :

    • Institute for Bioinformatics, GSF National Research Center for Environment and Health Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany
    • Technische Universität München, Chair of Genome Oriented Bioinformatics, Center of Life and Food Science D-85350 Freising-Weihenstephan, Germany

    Associated Country : Germany; Belgium; France; Germany


    Authors/Contributors : Gueldener U
    Contact Email : u.gueldener@gsf.de
    Year : 2006
    Language : English