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  1. MMBPred (View Publication)
    Resource Category : Webserver -> Protein -> Protein Sequence

    Brief Description : The server will predict mutated high affinity and promiscuous MHC class-I binding peptides from protein sequence. The prediction is based upon quantitative matrices generated in present study. The data for generation of quantitative matrices were drawn from MHCBN database. The server is useful in identification of mutated antigenic peptides when the natural protein is lacking in potential vaccine canidadtes. The server will predict the promiscuous mutated MHC class I binding peptides by introducing mutations at one,two or three positions. These peptides are crucial in overcoming the barriers of MHC restriction and subunit vaccine design.The server also facilitate the prediction of mutated high affinity MHC binding peptides as compared to native peptides. This procedure is known as epitope enhancement.
    Subject Area : Pepride Prediction; Immunology; Protein Sequence


    Institute/s :
    Institute of Microbial Technology, Chandigarh, INDIA
    Address of Institute/s :
    Bioinformatics Centre, Institute of Microbial Technology, Sector 39A, Chandigarh, INDIA
    State : Chandigarh, UT
    Country : India


    Authors/Contributors : Manoj Bhasin; G P S Raghava
    Contact Email : raghava@imtech.res.in
    Year : 2003
    Language : English

    Keywords : Algorithms; Alleles; Amino Acid Sequence; Binding Sites; Computational Biology; Computers; Conserved Sequence; Databases, Protein; Histocompatibility Antigens Class I / genetics; Internet; Major Histocompatibility Complex / genetics; Models, Biological; Mutation; Oligopeptides / chemistry / genetics; Reproducibility of Results; Sequence Analysis, Protein; User-Computer Interface