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  1. Lipase Engineering DB (View Publication)
    Full Name of the Resource : Sequence, structure and function of lipases and esterases
    Resource Category : Databases -> Protein Sequence Databases -> Databases of Individual Protein Families

    Brief Description : The Lipase Engineering Database (http://www.led.uni-stuttgart.de) integrates information on sequence, structure, and function of lipases, esterases, and related proteins. Sequence data on 806 protein entries are assigned to 38 homologous families, which are grouped into 16 superfamilies with no global sequence similarity among each other. For each family, multisequence alignments are provided with functionally relevant residues annotated. Pre-calculated phylogenetic trees allow navigation inside superfamilies. Experimental structures of 45 proteins are superposed and consistently annotated. The Lipase Engineering Database has been applied to systematically analyze sequence-structure-function relationships of this vast and diverse enzyme class. It is a useful tool to identify functionally relevant residues apart from the active site residues, and to design mutants with desired substrate specificity.
    Subject Area : Lipases, Esterases


    Institute/s :
    Institute of Technical Biochemistry University of Stuttgart Allmandring 31 D-70569 Stuttgart, Germany
    Address of Institute/s :
    Institute of Technical Biochemistry University of Stuttgart Allmandring 31 D-70569 Stuttgart, Germany
    Country : Germany

    Associated Institutes :

    • Institute of Technical Biochemistry University of Stuttgart Allmandring 31 D-70569 Stuttgart, Germany

    Associated Country : Germany


    Authors/Contributors : Juergen Pleiss
    Contact Email : Juergen.Pleiss@po.uni-stuttgart.de
    Year : 2003
    Language : English

    Keywords : Amino Acid Sequence; Binding Sites; Databases, Protein; Esterases / chemistry / physiology; Internet; Lipase / chemistry / classification / physiology; Phylogeny; Protein Engineering; Sequence Alignment; Sequence Homology, Amino Acid; Software; Substrate Specificity