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  1. IUPHAR-DB
    Resource Category : Databases -> Metabolic and Signaling Pathways -> Signalling pathways

    Brief Description : The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single-nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided.

    Institute/s :
    University of Edinburgh, Edinburgh, UK
    Address of Institute/s :
    University of Edinburgh, Edinburgh, UK
    Country : UK

    Associated Institutes :

    • Centres for Cardiovascular Science and Neuroscience Research
    • The Queen\'s Medical Research Institute
    • Institute of Evolutionary Biology, Ashworth Labs
    • School of Informatics, University of Edinburgh, Edinburgh, UK
    • Laboratory of Genetics
    • National Institute of Mental Health, Bethesda, MD 20892-4405, USA
    • Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    • Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK
    • Institut de Recherches Servier, 92150 Suresnes, France
    • Management Division, GlaxoSmithKline, Harlow, CM19 5AW, UK
    • GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, UK
    • Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
    • Molecular Zoology Group, Institut de Genomique Fonctionelle de Lyon, Lyon, France
    • Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    • Venuvics Pharmaceuticals, Glenmoore, PA, USA
    • Department of Molecular & Medical Pharmacology, University of California, Los Angeles, CA 90095-1735, USA
    • Neurosciences Institute, The University of Dundee, Dundee, DD1 9SY, UK
    • Centre National de la Recherche Scientifique, Montpellier, France
    • Wyeth Research, Collegeville, PA 19426
    • GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    • HGNC, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK

    Associated Country : UK; USA; France; California


    Authors/Contributors : Anthony J. Harmar; Rebecca A. Hills; Edward M. Rosser; Martin Jones; O. Peter Buneman; Donald R. Dunbar; Stuart D. Greenhill; Valerie A. Hale; Joanna L. Sharman; Tom I. Bonner; William A. Catterall; Anthony P. Davenport; Philippe Delagrange; Colin T. Dollery; Steven M. Foord; George A. Gutman; Vincent Laudet; Richard R. Neubig; Eliot H. Ohlstein; Richard W. Olsen; John Peters; Jean-Philippe Pin; Robert R. Ruffolo; David B. Searls; Mathew W. Wright; Michael Spedding
    Contact Email : tony.harmar@ed.ac.uk, tharmar@mac.com
    Year : 2008
    Language : English


  2. IUPHAR-DB
    Resource Category : Databases -> Metabolic and Signaling Pathways -> Signalling pathways

    Brief Description : The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion channel subunits encoded by the human, rat and mouse genomes. These genes represent the targets of approximately one-third of currently approved drugs and are a major focus of drug discovery and development programs in the pharmaceutical industry. IUPHAR-DB provides a comprehensive description of the genes and their functions, with information on protein structure and interactions, ligands, expression patterns, signaling mechanisms, functional assays and biologically important receptor variants (e.g. single-nucleotide polymorphisms and splice variants). In addition, the phenotypes resulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorders) are described. The content of the database is peer reviewed by members of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR); the data are provided through manual curation of the primary literature by a network of over 60 subcommittees of NC-IUPHAR. Links to other bioinformatics resources such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided.

    Institute/s :
    Centres for Cardiovascular Science and Neuroscience Research
    The Queen\'s Medical Research Institut
    Institute of Evolutionary Biology
    Ashworth Labs
    School of Informatics

    Address of Institute/s :
    University of Edinburgh, Edinburgh
    Country : UK

    Associated Institutes :

    • Centres for Cardiovascular Science and Neuroscience Research, The Queen\'s Medical Research Institute, Institute of Evolutionary Biology, Ashworth Labs, School of Informatics, University of Edinburgh, Edinburgh, UK
    • Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892-4405, USA
    • Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    • Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK
    • Institut de Recherches Servier, 92150 Suresnes, France
    • Management Division, GlaxoSmithKline, Harlow, CM19 5AW, UK
    • GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, UK
    • Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
    • Molecular Zoology Group, Institut de Genomique Fonctionelle de Lyon, Lyon, France
    • Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA
    • Venuvics Pharmaceuticals, Glenmoore, PA, USA
    • Department of Molecular & Medical Pharmacology, University of California, Los Angeles, CA 90095-1735, USA
    • Neurosciences Institute, The University of Dundee, Dundee, DD1 9SY, UK
    • Centre National de la Recherche Scientifique, Montpellier, France
    • Wyeth Research, Collegeville, PA 19426
    • GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    • HGNC, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK

    Associated Country : United Kingdom; USA; France


    Authors/Contributors : Anthony J. Harmar; Rebecca A. Hills; Edward M. Rosser; Martin Jones; O. Peter Buneman; Donald R. Dunbar; Stuart D. Greenhill; Valerie A. Hale; Joanna L. Sharman; Tom I. Bonner; William A. Catterall; Anthony P. Davenport; Philippe Delagrange; Colin T. Dollery; Steven M. Foord; George A. Gutman; Vincent Laudet; Richard R. Neubig; Eliot H. Ohlstein; Richard W. Olsen; John Peters; Jean-Philippe Pin; Robert R. Ruffolo; David B. Searls; Mathew W. Wright Michael Spedding
    Contact Email : tony.harmar@ed.ac.uk
    Year : 2008
    Language : English