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  1. IRESite (View Publication)
    Full Name of the Resource : Experimentally studied internal ribosome entry sites
    Resource Category : Databases -> RNA -> RNA Sequence, Structure and Functions

    Brief Description : IRESite is a searchable collection of data concerning the Internal Ribosome Entry Segments (IRES) both of viral and cellular origin. IRESs are the RNA regions which are mostly defined functionally by their ability to attract a eukaryotic ribosomal translation initiation complex independently of presence of the commonly utilized 5'-terminal 7mG cap structure and thus to promote translation initiation even at the internal part of the RNA molecule. IRESite can provide a broad set of information referring to particular IRES - briefly: primary sequence data, functional data, RNA structure and possible ribosomal RNA complementarity data, RNA:protein interaction data, links to primary databases, information about the relevant experiments and more. Most of the data are not available in the primary databases and are manually extracted from literature sources by IRESite curators. New data can also be submitted through the publicly available IRESite web interface after creating a personal account, however their release needs the curators' approval.
    Subject Area : Internal Ribosome Entry Segments


    Institute/s :
    Charles University, Faculty of Science, Department of Genetics and Microbiology, Czech Republic.
    Address of Institute/s :
    Charles University, Faculty of Science, Department of Genetics and Microbiology, Vinicna 5, Prague 2, 128 44, Czech Republic. mmokrejs@iresite.org
    Country : Czech Republic

    Associated Institutes :

    • Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Vini?ná 5, 128 44, Prague 2, Czech Republic
    • University of Montpellier 2, CNRS, UMR 5235, Place Eugene Bataillon, F-34095 Montpellier, France
    • Centre of Biomedical Informatics, Institute of Computer Science AS CR, Pod Vodárenskou v?ží 2, 182 07, Prague 8, Czech Republic

    Associated Country : Czech Republic; France


    Authors/Contributors : Martin Mokrejš
    Contact Email : martin@natur.cuni.cz
    Year : 2009
    Language : English

    Keywords : 5' Untranslated Regions / chemistry; Databases, Nucleic Acid; Internet; Peptide Chain Initiation, Translational; Peptide Initiation Factors / metabolism; Plasmids / chemistry; Promoter Regions, Genetic; RNA, Messenger / chemistry; RNA, Viral / chemistry; Regulatory Sequences, Ribonucleic Acid; User-Computer Interface