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  1. IMGT (View Publication)
    Full Name of the Resource : International immunogenetics information system: Immunoglobulins, T cell receptors, MHC, and RPI
    Resource Category : Databases -> Immunological Databases -> Immunological Databases

    Brief Description : IMGT?, the international ImMunoGeneTics information system?, created in 1989 by Marie-Paule Lefranc (Universitere Montpellier 2, CNRS, Montpellier, France), is a high-quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), and major histocompatibility complex (MHC) of human and other vertebrate species, and related proteins of the immune system (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF) (1,2). IMGT? provides a common access to expertly annotated nucleotide and protein sequences, structural data and genetic information for the molecules of the immune system (3,4). IMGT? includes: (i) five databases: IMGT/LIGM-DB (5), a comprehensive database of more than 122,400 IG and TR sequences from human and from 221 other vertebrate species in April 2008, IMGT/MHC-DB hosted at EBI [which comprises IMGT/MHC-HLA (ANRI), IMGT/MHC-NHP (BPRC)], IMGT/PRIMER-DB(LIGM, Montpellier), IMGT/GENE-DB (6),IMGT/3Dstructure-DB (7), (ii) Web resources: 10,000 HTML pages (\'IMGT Marie-Paule page\') which comprise locus representations, gene tables, allele alignments, 2D graphical representations (or IMGT Colliers de Perles), 3D representations (IMGT Repertoire for IG and TR, MHC, RPI), IMGT Scientific chart rules based on the IMGT-ONTOLOGY axioms and concepts (8,9), educational pages (IMGT Education), numerous hyperlinks to external Web servers (IMGT Bloc-notes), a referential index (IMGT Index), (iii) interactive tools: IMGT/V-QUEST (10), IMGT/JunctionAnalysis (11), IMGT/PhyloGene (12), IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView, IMGT/GeneInfo (13), IMGT/StructuralQuery. Since July 1995, IMGTĀ® has been available on the Web at http://imgt.cines.fr. IMGT? databases, tools and Web resources are extensively queried and used by scientists from both academic and industrial laboratories. IMGT? is used in very diverse domains: (i) fundamental and medical research (repertoire analysis of the IG antibody recognition sites and of the TR recognition sites in normal and pathological situations such as autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas, and myelomas), (ii) veterinary research (IG and TR repertoires in farm and wildlife species), (iii) genome diversity and genome evolution studies of the adaptive immune responses, (iv) structural evolution of the IgSF and MhcSF proteins, (v) biotechnology related to antibody engineering [single chain Fragment variable (scFv), phage displays, combinatorial libraries, chimeric, humanized, and human antibodies], (vi) diagnostics (clonalities, detection, and follow-up of residual diseases), and (vii) therapeutical approaches (grafts, immunotherapy, and vaccinology).

    Institute/s :
    Universite Montpellier 2, CNRS, Montpellier, France.
    Address of Institute/s :
    Universite Montpellier 2, CNRS, Montpellier, France.
    Country : France

    Associated Institutes :

    • IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire de'ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

    Associated Country : France


    Authors/Contributors : Lefranc, M.-P.
    Contact Email : Marie-Paule.Lefranc@igh.cnrs.fr
    Year : 2008
    Language : English

    Keywords : Amino Acid Sequence; Animals; Complementarity Determining Regions / genetics; *Databases, Genetic; Genome; Humans; Immunoglobulins / chemistry / classification / *genetics; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Proteome / genetics; Receptors, Antigen, T-Cell / chemistry / classification / *genetics