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  1. IARC TP53 Database (View Publication)
    Full Name of the Resource : IARC TP53 Database
    Resource Category : Databases -> Human Genes and Diseases -> Cancer Gene Databases

    Brief Description : Human TP53 somatic and germline mutations
    Subject Area : Germline Mutation; Cancer


    Institute/s :
    Molecular Carcinogenesis Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
    Address of Institute/s :
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, 69372 Lyon cedex 08, France
    Molecular Epidemiology Unit, Leeds Institute of Genetics, University of Leeds, Leeds, UK
    Laboratory of Human Carcinogenesis, Building 37, Room 2C05, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA

    Country : France

    Associated Institutes :

    • Group of Molecular Carcinogenesis, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, 69372 Lyon cedex 08, France
    • Molecular Epidemiology Unit, Leeds Institute of Genetics, University of Leeds, Leeds, UK
    • Laboratory of Human Carcinogenesis, Building 37, Room 2C05, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA

    Associated Country : France; United Kingdom; USA


    Authors/Contributors : Olivier, M.
    Contact Email : TP53databaseHelp@iarc.fr
    Year : 2002
    Language : English

    Keywords : Computational Biology/methods; DNA Mutational Analysis/*methods; *Databases, Genetic/trends; Genes, Tumor Suppressor; Genes, p53/*genetics; Humans; *Internet; Li-Fraumeni Syndrome/genetics; Mutation/genetics


  2. IARC TP53 Database
    Full Name of the Resource : Human TP53 somatic and germline mutations
    Resource Category : Databases -> Human Genes and Diseases -> Cancer Gene Databases

    Brief Description : The IARC TP53 database is a public web-based resource for the analysis and interpretation of the biological and clinical impacts of TP53 gene variations in human cancers (http://www-p53.iarc.fr/). It contains data that are compiled from the peer-reviewed scientific literature or generalist databases. It includes annotations on predicted or experimentally assessed functional and structural impacts of mutations, as well as on tumor pathology and patient demographics and life-styles. There are five integrated datasets (somatic mutations, germline mutations, polymorphisms, biological activities of mutant proteins, mouse-models) that can be fully downloaded. The database can be search through an interactive web interface that allows for the selection, analysis and download of specific sets of data according to user’s query. The web site also provides a comprehensive user guide, a slide-show on TP53 mutations in human cancer, protocols and references for sequencing the TP53 gene, and links to relevant publications and entries to other related cancer databases. With over 25,000 somatic and 500 germline mutations and 2,000 citations in the world literature, this database is recognized as a major source of information on TP53 mutation patterns in human cancer. The database is meant to be a resource for a broad range of scientists and clinicians who work in different research areas: (1) basic research, to study the structural and functional aspects of the p53 protein; (2) molecular pathology of cancer, to understand the clinical significance of mutations identified in cancer patients; (3) molecular epidemiology of cancer, to investigate links between specific exposures and mutation patterns and to make inferences about possible causes of cancer; (4) molecular genetics, to study genotype/phenotype associations.

    Institute/s :
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, 69372 Lyon cedex 08, France
    Molecular Epidemiology Unit, Leeds Institute of Genetics, University of Leeds, Leeds, UK
    Laboratory of Human Carcinogenesis, Building 37, Room 2C05, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA

    Country : France; United Kingdom; USA


    Year : 1998