Advance Search              Latest Recources





















Showing search results (1–1 of 1):

  1. HomoloGene
    Full Name of the Resource : Automatically detected homologous genes in complete eukaryotic genomes
    Resource Category : Databases -> Human and Other Vertebrate Genomes -> Model Organisms, Comparative Genomics

    Brief Description : The availability of an increasing number of fully sequenced genomes is opening up many new avenues for comparative genomics. HomoloGene is a system for automatically arranging genes into putative homology groups. The starting gene sets are derived from the gene annotation of over a dozen sequenced eukaryotic genomes. The overall process of grouping genes is guided by an evolutionary tree. Starting with the most closely related groups of organisms, DNA-based alignment measures are used together with conserved gene order to identify clear-cut paralogs and othologs. Following this, protein-based similarity measures are used to identify ancient relationships and extended gene families. Interactive access is provided through the NCBI?s Entrez system. HomoloGene views provide sequence alignments and conserved protein domain structure. In addition, ancillary information is included, where available, thereby providing links to the phenotypic information and the published literature.

    Institute/s :
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Country : United States

    Associated Institutes :

    • National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA

    Associated Country : USA


    Authors/Contributors : David L. Wheeler
    Contact Email : info@ncbi.nlm.nih.gov
    Year : 2006