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  1. HIV RT and Protease Sequence Database (View Publication)
    Full Name of the Resource : HIV RT and Protease Sequence Database
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Viral Genome Databases

    Brief Description : The HIV Reverse Transcriptase and Protease Sequence Database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral therapy (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions to GenBank, sequences published in journal articles, and sequences of HIV isolates from persons participating in clinical trials. Sequences are linked to data about the source of the sequence, the antiretroviral drug treatment history of the person from whom the sequence was obtained and the results of in vitro drug susceptibility testing. Sequence data on two new molecular targets of HIV drug therapy ¯ gp41 (cell fusion) and integrase ¯ will be added to the database shortly.
    Subject Area : HIV; Protease Sequence; HIV Reverse Transcriptase


    Institute/s :
    Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA
    Address of Institute/s :
    Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA
    Country : United States

    Associated Institutes :

    • Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA 94305, USA

    Associated Country : USA


    Contact Email : rshafer@stanford.edu
    Year : 1999
    Language : English

    Keywords : Anti-HIV Agents/pharmacology/therapeutic use; *Databases, Factual/trends; Drug Resistance, Microbial/genetics; Drug Therapy, Combination; Evolution, Molecular; Genes, Viral/genetics; Genetic Variation/genetics; HIV/chemistry/drug effects/genetics; HIV Infections/drug therapy/virology; HIV Protease/chemistry/*genetics; HIV Reverse Transcriptase/chemistry/*genetics; Humans; Information Storage and Retrieval; Internet; Mutation/genetics; Polymorphism, Genetic/genetics; Sequence Alignment


  2. HIV RT and Protease Sequence Database (View Publication)
    Full Name of the Resource : HIV reverse transcriptase and protease sequences
    Resource Category : Databases -> Protein Sequence Databases -> Databases of Individual Protein Families

    Brief Description : The HIV Reverse Transcriptase and Protease Sequence Database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral therapy (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions to GenBank, sequences published in journal articles, and sequences of HIV isolates from persons participating in clinical trials. Sequences are linked to data about the source of the sequence, the antiretroviral drug treatment history of the person from whom the sequence was obtained and the results of in vitro drug susceptibility testing. Sequence data on two new molecular targets of HIV drug therapy ¯ gp41 (cell fusion) and integrase ¯ will be added to the database shortly.
    Subject Area : HIV Reverse Transcriptase, Protease Sequences


    Institute/s :
    Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA
    Address of Institute/s :
    Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA
    Country : United States

    Associated Institutes :

    • Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA 94305, USA

    Associated Country : USA


    Authors/Contributors : Shafer, R.W.
    Contact Email : rshafer@stanford.edu
    Year : 2003
    Language : English

    Keywords : Amino Acid Sequence; Anti-HIV Agents / therapeutic use; Databases, Protein; Drug Design; Drug Resistance, Viral; Genetic Variation; HIV Infections / drug therapy; HIV Protease / genetics; HIV Protease Inhibitors / therapeutic use; HIV Reverse Transcriptase / antagonists & inhibitors / genetics; HIV-1 / drug effects / isolation & purification; Humans; Mutation; Phenotype; Sequence Alignment; Sequence Analysis, Protein