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  1. HIV Positive Selection Mutation Database (View Publication)
    Full Name of the Resource : Positively selected mutations in HIV-1 protease and reverse transcriptase
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Viral Genome Databases

    Brief Description : Drug resistance is a major problem in the treatment of AIDS, due to the very high mutation rate of human immunodeficiency virus (HIV) and subsequent rapid development of resistance to new drugs. Identification of mutations associated with drug resistance is critical for both individualized treatment selection and new drug design. We have performed an automated mutation analysis of HIV Type 1 (HIV-1) protease and reverse transcriptase (RT) from approximately 50,000 AIDS patient plasma samples sequenced by Specialty Laboratories Inc. from 1999 to mid-2002. This dataset provides a nearly complete mutagenesis of HIV protease and enables the calculation of statistically significant Ka/Ks values for each individual amino acid mutation in protease and RT. Positive selection (i.e., Ka/Ks>1 indicating increased reproductive fitness) detected 19 of 23 known drug-resistant mutation positions in protease and 20 of 34 such positions in R
    Subject Area : AIDS; Immunology; Positive Selection - Reproductive Fitness


    Institute/s :
    Center for Computational Biology, Molecular Biology Institute, Institute for Genomics and Proteomics, University of California, USA
    Address of Institute/s :
    Center for Computational Biology, Molecular Biology Institute, Institute for Genomics and Proteomics, University of California, Los Angeles, CA, USA
    Country : United States

    Associated Institutes :

    • Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA

    Associated Country : USA


    Authors/Contributors : Calvin Pan; Joseph Kim; Lamei Chen; Qi Wang; Christopher Lee
    Contact Email : leec@chem.ucla.edu
    Year : 2007
    Language : English

    Keywords : Acquired Immunodeficiency Syndrome/drug therapy/virology; Codon; DNA Mutational Analysis; *Databases, Genetic; Drug Resistance, Viral/genetics; HIV Protease/*genetics; HIV Protease Inhibitors/therapeutic use; HIV Reverse Transcriptase/*genetics; HIV-1/drug effects/genetics; Humans; Internet; *Mutation; Reverse Transcriptase Inhibitors/therapeutic use; Selection, Genetic; User-Computer Interface


  2. HIV Positive Selection Mutation Database
    Full Name of the Resource : Positively selected mutations in HIV-1 protease and reverse transcriptase
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Viral Genome Databases


    Institute/s :
    Center for Computational Biology, University of California Los Angeles, CA, USA
    Molecular Biology Institute, Institute for Genomics and Proteomics, University of California Los Angeles, CA, USA
    Department of Chemistry and Biochemistry, University of California Los Angeles, CA, USA

    Address of Institute/s :
    Center for Computational Biology, University of California Los Angeles, CA, USA
    Molecular Biology Institute, Institute for Genomics and Proteomics, University of California Los Angeles, CA, USA
    Department of Chemistry and Biochemistry, University of California Los Angeles, CA, USA



    Authors/Contributors : Calvin Pan; Joseph Kim; Lamei Chen; Qi Wang; Christopher Lee
    Contact Email : leec@chem.ucla.edu
    Year : 2006