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  1. HIV Drug Resistance Database (View Publication)
    Full Name of the Resource : HIV mutations that confer resistance to anti-HIV drugs
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Viral Genome Databases

    Brief Description : The HIV Drug Resistance Database is a compilation of mutations in HIV genes that confer resistance to anti-HIV drugs. Currently, 673 mutations to RT, Protease, Env, Gag, Integrase, FIV RT and SIV RT are stored. The database may be searched by gene, compound, drug class, amino acid position, and other fields; there is a browse facility as well. The Antiviral Drug Resistance Analysis program (http://www.hiv.lanl.gov/content/hiv-db/ADRA/adra.html), available on the site, analyzes user-submitted nucleotide sequences for mutations known to confer drug resistance and links to the records in the database. There is also a program that allows plotting of selected mutations onto a 3-D structure of Protease or RT. The database is published annually as "Mutations in Retroviral Genes Associated with Drug Resistance" in the HIV Sequence Compendium, http://www.hiv.lanl.gov/content/hiv-db/REVIEWS/reviews.html.
    Subject Area : HIV Drug Resistance; Human Immuno Deficiency Virus


    Institute/s :
    Los Alamos National Laboratory, USA
    Address of Institute/s :
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Country : United States

    Associated Institutes :

    • Los Alamos National Laboratory, Los Alamos, NM 87545, USA

    Associated Country : USA


    Authors/Contributors : Charles E. Calef
    Contact Email : ccalef@lanl.gov
    Year : 2007
    Language : English

    Keywords : Anti-HIV Agents/*therapeutic use; Antiretroviral Therapy, Highly Active; *Databases as Topic; *Drug Resistance, Viral; Great Britain; HIV Infections/*drug therapy; HIV Protease Inhibitors/therapeutic use; Humans