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  1. Epitome (View Publication)
    Full Name of the Resource : Antigenic epitopes in proteins and antibodies that bind them
    Resource Category : Databases -> Immunological Databases -> Immunological Databases

    Brief Description : Epitome is a database of all known antigenic residues and the antibodies that interact with them, including a detailed description of the residues involved in the interaction and their sequence/structure environments. Each entry in the database describes one interaction between a residue on an antigenic protein and a residue on an antibody chain. Every interaction is described using the following parameters: (1) PDB identifier, (2) antigen chain ID (3) PDB position of the antigenic residue, (4) type of antigenic residue and its sequence environment, (5) antigen residue secondary structure state, (6) antigen residue solvent accessibility, (7) antibody chain ID, (8) type of antibody chain (heavy or light), (9) CDR number, (10) PDB position of the antibody residue, and (11) type of antibody residue and its sequence environment. Additionally, interactions can be visualized using an interface to Jmol. The database is available at http://www.rostlab.org/services/epitome/.

    Institute/s :
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, USA
    Address of Institute/s :
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University 1130 St Nicholas Avenue room 804, New York, NY 10032, USA
    Country : United States

    Associated Institutes :

    • CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University 1130 St Nicholas Avenue room 804, New York, NY 10032, USA
    • Columbia University Center for Computational Biology and Bioinformatics (C2B2) 1130 St Nicholas Avenue room 804, New York, NY 10032, USA
    • NorthEast Structural Genomics Consortium (NESG), Department of Biochemistry and Molecular Biophysics, Columbia University 1130 St. Nicholas Avenue room 804, New York, NY 10032, USA

    Associated Country : USA


    Authors/Contributors : Schlessinger A.
    Contact Email : as2067@columbia.edu
    Year : 2006
    Language : English

    Keywords : Binding Sites, Antibody; Complementarity Determining Regions / *chemistry / immunology; *Databases, Protein; Epitopes, B-Lymphocyte / *chemistry / immunology; Internet; Models, Molecular; Proteins / chemistry / *immunology; User-Computer Interface