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  1. EchoBASE (View Publication)
    Full Name of the Resource : Post-genomic studies of Escherichia coli
    Resource Category : Databases -> Genomic Databases (Non-Human) -> Escherichia coli

    Brief Description : EchoBASE is a relational database designed to contain and manipulate information from post-genomic experiments using the model bacterium Escherichia coli K-12. Its aim is to collate information from a wide range of sources to provide clues to the functions of the approximately 1500 gene products that have no confirmed cellular function. The database is built on an enhanced annotation of the updated genome sequence of strain MG1655 and associates experimental data with the E. coli genes and their products. Experiments that can be held within EchoBASE include proteomics studies, microarray data, protein-protein interaction data, structural data and bioinformatic studies. Proteomics studied of E. coli are well covered in the database and complex queries can be made to establish the totality of the experimentally determined proteome, or of particular sub-proteome. Validation of FUN gene products by proteomics is an important criterion in choosing which to study and EchoBASE currently has data for 254 FUN genes whose synthesis has been confirmed experimentally. EchoBASE also contains annotated information on 'orphan' enzyme activities from this microbe to aid characterisation of the proteins that catalyse these elusive biochemical reactions.
    Subject Area : Escherichia coli


    Institute/s :
    Department of Biology, University of York, United Kingdom
    Address of Institute/s :
    Department of Biology (Area 10), University of York, PO Box 373,York, YO10 5YW, UK
    Country : United Kingdom

    Associated Institutes :

    • Department of Biology (Area 10), University of York, PO Box 373,York, YO10 5YW, UK
    • Scientific Computing and Mathematical Modelling, GlaxoSmithKline, Gunnels Wood Road, Stevenage, UK

    Associated Country : United Kingdom


    Authors/Contributors : G.H. Thomas
    Contact Email : ght2@york.ac.uk
    Year : 2005
    Language : English

    Keywords : Databases, Genetic; Escherichia coli K12 / enzymology / genetics / metabolism; Escherichia coli Proteins / chemistry / genetics / physiology; Genome, Bacterial; Genomics; Systems Integration; User-Computer Interface