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  1. ESTHER (View Publication)
    Full Name of the Resource : Esterases and other alpha / beta hydrolase enzymes
    Resource Category : Databases -> Protein Sequence Databases -> Databases of Individual Protein Families

    Brief Description : Acetylcholinesterase belongs to a family of proteins, the alpha / beta hydrolase fold family, whose constituents evolutionary diverged from a common ancestor and share a similar structure of a central beta-sheet surrounded by alpha-helices. These proteins fulfill a wide range of physiological functions (hydrolases, adhesion molecules, hormone precursors). ESTHER (for esterases, alpha / beta hydrolase enzyme and relatives) is a database whose aim is to group in one information system, sequence data together with annotations and experimental biochemical results related to the sructure-function analysis of the enzymes of the family. The database provides numerous links to generalist databases (e.g., Genbank-EMBL SWISS-PROT, and MEDLINE). It includes inhibitors, substrates, kinetic-parameters. The database management system is ACeDB designed by Richard Durbin and Jean Thierry-Mieg. The web interface uses ACEPerl from Lincoln Stein. New tools allow rapid navigation from alignement of sequences or summaries of mutation studies to three dimensional structure representation and kinetic parameters mesured on the modified enzymes. Complex queries are made possible by the new development and can be reached at http: / / www.ensam.inra.fr / cholinesterase.
    Subject Area : Acetylcholinesterase


    Institute/s :
    Informatique INRA place Viala 34080 Montpellier, France
    Address of Institute/s :
    Differenciation Cellulaire et Croissance Departement Physiologie Animale INRA place Viala 34080 Montpellier
    Unite Informatique INRA place Viala 34080 Montpellier

    Country : France

    Associated Institutes :

    • UIC INRA?AgroM, Place Viala, 34060 Montpellier, France
    • UMR?6560 CNRS Ingénierie des protéines, IFR Jean Roche, Université de la Méditerranée, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    • UMR?866 INRA?UMII?AgroM Différenciation Cellulaire et Croissance, Montpellier, France

    Associated Country : France


    Authors/Contributors : Chatonnet, A.
    Contact Email : chatonne@ensam.inra.fr
    Year : 2004
    Language : English

    Keywords : Animals; Computational Biology; Databases, Protein; Humans; Hydrolases / chemistry; Internet; Protein Folding; Protein Structure, Secondary; Proteins / chemistry / classification; Sequence Alignment; Structural Homology, Protein