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  1. EHCO (View Publication)
    Full Name of the Resource : EHCO
    Resource Category : Databases -> Human Genes and Diseases -> Cancer Gene Databases

    Brief Description : Encyclopedia of hepatocellular carcinoma genes online
    Subject Area : Cancer Gene; Carcinoma


    Institute/s :
    Institute of Information Science, Academia Sinica, Taiwan
    Address of Institute/s :
    Institute of Information Science, Academia Sinica, Taipei 115, Taiwan
    Department of Life Science, Fu-Jen Catholic University, Taipei Hsien 242, Taiwan
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan
    Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan
    Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
    National Center for High-performance Computing, Hsinchu 300, Taiwan
    Institute of Bio-Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
    Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Insititute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan

    Country : Taiwan

    Associated Institutes :

    • Institute of Information Science, Academia Sinica, Taipei 115, Taiwan
    • Department of Life Science, Fu-Jen Catholic University, Taipei Hsien 242, Taiwan
    • Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan
    • Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan
    • Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan
    • Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
    • National Center for High-performance Computing, Hsinchu 300, Taiwan
    • Institute of Bio-Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
    • Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei 112, Taiwan
    • Insititute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan.

    Associated Country : Taiwan


    Authors/Contributors : Hsu, C. N.
    Contact Email : chunnan@iis.sinica.edu.tw
    Year : 2007
    Language : English

    Keywords : Carcinoma, Hepatocellular/*genetics; *Encyclopedias as Topic; Gene Expression Profiling/methods; Gene Expression Regulation, Neoplastic/genetics; Gene Regulatory Networks/*genetics; Humans; Liver Neoplasms/*genetics; Oligonucleotide Array Sequence Analysis/methods


  2. EHCO
    Full Name of the Resource : Encyclopedia of hepatocellular carcinoma genes online
    Resource Category : Databases -> Human Genes and Diseases -> Cancer Gene Databases

    Brief Description : The significant advances in microarray and proteomics analyses has resulted in an exponential increase in potential new targets and has promised to shed light on the identification of disease markers and cellular pathways. We aim to collect and decipher the HCC-related genes at the systems level. Here, we build an integrative platform, the Encyclopedia of Hepatocellular Carcinoma genes Online, dubbed EHCO, to systematically collect, organize and compare the pileup of unsorted HCC-related studies by using natural language processing and softbots. Among the eight gene set collections, ranging across PubMed, SAGE, microarray, and proteomics data, there are 2,906 genes in total; however, more than 77% genes are only included once, suggesting that tremendous efforts need to be exerted to characterize the relationship between HCC and these genes. Of these HCC inventories, protein binding represents the largest proportion (~25%) from Gene Ontology analysis. In fact, many differentially expressed gene sets in EHCO could form interaction networks (e.g. HBV-associated HCC network) by using available human protein-protein interaction datasets. To further highlight the potential new targets in the inferred network from EHCO, we combine comparative genomics and interactomics approaches to analyze 120 evolutionary conserved and overexpressed genes in HCC. 47 out of 120 queries can form a highly interactive network with 18 queries serving as hubs. This architectural map may represent the first step toward the attempt to decipher the hepatocarcinogenesis at the systems level. Targeting hubs and/or disruption of the network formation might reveal novel strategy for HCC treatment. EHCO can be freely accessed through http://ehco.iis.sinica.edu.tw.

    Institute/s :
    Institute of Information Science, Academia Sinica, Taipei 115, Taiwan
    Department of Life Science, Fu-Jen Catholic University, Taipei Hsien 242, Taiwan
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan
    Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan
    Department of Computer Science and Information Engineering, National Taiwan University, Taipei 106, Taiwan
    Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
    National Center for High-performance Computing, Hsinchu 300, Taiwan
    Institute of Bio-Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan
    Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Insititute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan.

    Country : Taiwan


    Authors/Contributors : Hsu C.-N
    Contact Email : chunnan@iis.sinica.edu.tw
    Language : English