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  1. DomIns (View Publication)
    Full Name of the Resource : Database of Domain Insertions
    Resource Category : Databases -> Protein Sequence Databases -> Protein Domain Databases (Protein Classification)

    Brief Description : Proteins can be formed by single or multiple domains. The process of recombination at the molecular level has generated a wide variety of multi-domain proteins with specific domain organization to cater to the functional requirements of an organism. The functional and structural costs of inserting a domain into another means that multi-domain proteins are usually formed by covalently linking the N-terminus of one domain to the C-terminus of the preceding domain. While this is true in a large proportion of multi-domain proteins, we find a significant fraction of proteins that are the result of domain insertion. The inserted domain breaks the sequence contiguity of the domain into which it is inserted leading to a novel domain organization. This web resource aims to document domain insertions in known protein structures that are classified in the SCOP database. The web server can be accessed from http://www.domins.org.
    Subject Area : Protein Domain


    Institute/s :
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    Address of Institute/s :
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

    Country : United Kingdom

    Associated Institutes :

    • The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

    Associated Country : United Kingdom


    Authors/Contributors : R Aroul Selvam; Rajkumar Sasidharan
    Contact Email : rajkumar.sasidharan@yale.edu
    Year : 2004
    Language : English

    Keywords : Amino Acid Sequence; Animals; Computational Biology; Databases, Protein; Humans; Information Storage and Retrieval; Internet; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Proteins /chemistry; Recombination, Genetic


  2. DomIns (View Publication)
    Full Name of the Resource : Database of Domain Insertions
    Resource Category : Databases -> Protein Sequence Databases -> Protein Domain Databases (Protein Classification)

    Brief Description : Proteins can be formed by single or multiple domains. The process of recombination at the molecular level has generated a wide variety of multi-domain proteins with specific domain organization to cater to the functional requirements of an organism. The functional and structural costs of inserting a domain into another means that multi-domain proteins are usually formed by covalently linking the N-terminus of one domain to the C-terminus of the preceding domain. While this is true in a large proportion of multi-domain proteins, we find a significant fraction of proteins that are the result of domain insertion. The inserted domain breaks the sequence contiguity of the domain into which it is inserted leading to a novel domain organization. This web resource aims to document domain insertions in known protein structures that are classified in the SCOP database. The web server can be accessed from http://www.domins.org.
    Subject Area : Domain Interactions


    Institute/s :
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
    Address of Institute/s :
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK .

    Country : United Kingdom

    Associated Institutes :

    • The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    • MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

    Associated Country : United Kigdom


    Authors/Contributors : Sasidharan Rajkumar
    Contact Email : rajkumar.sasidharan@yale.edu, sraj@mrc?lmb.cam.ac.uk
    Year : 2004
    Language : English

    Keywords : Amino Acid Sequence; Animals; Computational Biology; *Databases, Protein; Humans; Information Storage and Retrieval; Internet; Models, Molecular; Molecular Sequence Data; *Protein Structure, Tertiary; Proteins / *chemistry; *Recombination, Genetic