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  1. DG-CST (View Publication)
    Full Name of the Resource : Disease gene conserved sequence tags
    Resource Category : Databases -> Human Genes and Diseases -> General Human Genetics Databases

    Brief Description : The DG-CST database is a collection of conserved sequence elements, identified by a systematic genomic sequence comparison between a set of human genes involved in the pathogenesis of genetic disorders and their murine counterparts. Human and Mouse genomic sequences were compared by BLASTZ, an independent implementation of the Gapped BLAST algorithm, specifically designed for aligning two long genomic sequences (http://bio.cse.psu.edu). Sequences longer than 100 and with identity better than 70% were selected as CSTs and imported into the DB. CSTs are extensively annotated with respect to exon/intron structure and other biological parameters. CST counterparts in other species were identified by using BLAST to scan genomes from other species, and selecting on the basis of homology and colinearity.

    Institute/s :
    Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
    Address of Institute/s :
    Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
    Country : Italy

    Associated Institutes :

    • CEINGE Biotecnologie Avanzate, Italy
    • Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
    • FIRC Institute of Molecular Oncology Foundation (IFOM), Italy
    • Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita' di Milano, Milan, Italy
    • Dipartimento di Scienze Animali, Vegetali e dell'Ambiente, Universita' del Molise, Campobasso, Italy
    • BioGeM Consortium, Italy
    • Medical Genetics, Department of Pediatrics, Federico II University, Naples, Italy

    Associated Country : Italy


    Authors/Contributors : Angelo Boccia; Mauro Petrillo; Diego di Bernardo; Alessandro Guffanti; Flavio Mignone; Stefano Confalonieri; Lucilla Luzi; Graziano Pesole; Giovanni Paolella; Andrea Ballabio; Sandro Banfi
    Contact Email : banfi@tigem.it
    Year : 2005

    Keywords : Animals; Base Sequence; Computer Graphics; Conserved Sequence; Databases, Nucleic Acid; Genetic Predisposition to Disease; Genomics; Humans; Mice; User-Computer Interface