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  1. Cyclonet (View Publication)
    Full Name of the Resource : Database on cell cycle regulation
    Resource Category : Databases -> Metabolic and Signaling Pathways -> Protein-Protein Interactions

    Brief Description : Computational modelling of mammalian cell cycle regulation is a challenging task, which requires comprehensive knowledge on many interrelated processes in the cell. We have developed a web-based integrated database on cell cycle regulation in mammals in normal and pathological states (Cyclonet database, http://cyclonet.biouml.org/). It integrates data obtained by "omics" sciences and chemoinformatics on the basis of systems biology approach. Cyclonet is a specialized resource, which enables researchers working in the field of anticancer drug discovery to analyze the wealth of currently available information in a systematic way. Cyclonet contains information on relevant genes and molecules; diagrams and models of cell cycle regulation and results of their simulation; microarray data on cell cycle and on various types of cancer, information on drug targets and their ligands, as well as extensive bibliography on modelling of cell cycle and cancer related gene expression data. Cyclonet database is also accessible through BioUML workbench, which allows flexible querying, analyzing and editing the data by means of visual modelling. Cyclonet aims to predict promising anticancer targets and their agents by application of PASS (Prediction of Activity Spectra for Substances).

    Institute/s :
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyev Avenue, Novosibirsk, Russia
    Address of Institute/s :
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences 10, Lavrentyev Avenue, Novosibirsk 630090, Russia
    Country : Russia

    Associated Institutes :

    • Institute of Systems Biology, 15, Detskiy proezd Novosibirsk 630090, Russia
    • Design Technological Institute of Digital Techniques, Siberian Branch of Russian Academy of Sciences 6, Institutskaya, Novosibirsk 630090, Russia
    • Institute of Biomedical Chemistry of Russian Academy of Medical Sciences 10, Pogodinskaya Street, Moscow 119121, Russia
    • Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences 10, Lavrentyev Avenue, Novosibirsk 630090, Russia
    • CNR-Institute of Biomedical Technologies, 93 Via Fratelli Cervi, Segrate (MI) 20090, Italy
    • BIOBASE GmbH, 33 Halchtersche Strasse, Wolfenbuettel 38304, Germany

    Associated Country : Russia; Italy; Germany


    Authors/Contributors : Fedor Kolpakov; Vladimir Poroikov; Ruslan Sharipov; Yury Kondrakhin; Alexey Zakharov; Alexey Lagunin; Luciano Milanesi; Alexander Kel
    Contact Email : shrus79@gmail.com
    Year : 2006

    Keywords : Animals; Antineoplastic Agents / pharmacology; Cell Cycle / genetics; Databases, Factual; Drug Design; Gene Expression Profiling; Genomics; Humans; Internet; Mammals / genetics / metabolism; Neoplasms / genetics / metabolism; Proteomics; Systems Biology; Systems Integration; User-Computer Interface