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  1. CoC Central (View Publication)
    Full Name of the Resource : Conservatism of Conservatism (CoC) database
    Resource Category : Databases -> Protein Sequence Databases -> Protein sequence motifs and active sites

    Brief Description : The Conservatism of Conservatism (CoC) database presents statistical analysis of the conservation of residue positions in folds across protein families. Residues with high CoC are conserved in families of homologous proteins that acquire the same fold. Such residues can be different in non-homologous proteins (analogues) that exhibit the same fold, but the common conservation points to the general importance of the residue positions. We calculate and present the statistical significance of such conservation and highlight residues that are more conserved than expected given the residue\'s solvent accessibility. Such high CoC residues have been shown to be crucial for the kinetics and/or thermodynamics of protein folding, are involved in folding nucleation, and are often identified in positions of functional importance such as "super-sites". More information is available at the website (http://kulibin.mit.edu/coc/).
    Subject Area : Conservatism of Conservatism; Protein Localisation


    Institute/s :
    Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
    Address of Institute/s :
    Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology 77 Massachusetts Avenue, 16–343, Cambridge, MA 02139, USA
    Country : United States

    Associated Institutes :

    • Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    • Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-343, Cambridge, MA 02139, USA

    Associated Country : USA


    Authors/Contributors : Leonid A. Mirny
    Contact Email : leonid@mit.edu
    Year : 2004
    Language : English

    Keywords : Conserved Sequence; Database Management Systems; *Databases, Protein; Information Storage and Retrieval / methods; Protein Folding; Proteins / chemistry / classification; Sequence Alignment / methods; Sequence Analysis, Protein / methods; Sequence Homology, Amino Acid; Software; User-Computer Interface