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  1. CentrosomeDB (View Publication)
    Full Name of the Resource : Compilation of Cetrosome
    Resource Category : Databases -> Protein Sequence Databases -> Protein Localization and Targeting

    Brief Description : Active research on the biology of the centrosome during the past decades has allowed the identification and characterization of many centrosomal proteins. Unfortunately, the accumulated data are still dispersed among heterogeneous sources of information. Here we present CentrosomeDB, which intends to compile and integrate information related to the human centrosome. We have compiled a set of 383 likely human centrosomal genes, and recorded the associated supporting evidence. CentrosomeDB offers several perspectives to study the human centrosome, including evolution, function, and structure. The database contains information on orthology relationships with other species, including fungi, nematodes, arthropods, urochordates and vertebrates. Predictions of the domain organization of CentrosomeDB proteins are graphically represented in different sections of the database, including sets of alternative protein isoforms, interacting proteins, groups of orthologs, and the homologs identified with blast. CentrosomeDB also contains information related to function, gene-disease associations, SNPs and the 3D structure of proteins. Apart from important differences in the coverage of the set of centrosomal genes, our database differentiates from other similar initiatives in the way information is treated and analyzed. CentrosomeDB is publicly availablec.
    Subject Area : Centrosome


    Institute/s :
    Computer Architecture Department. Complutense University of Madrid, Spain
    Address of Institute/s :
    Computer Architecture Department. Complutense University of Madrid, Spain
    Country : Spain

    Associated Institutes :

    • Computer Architecture Department. Complutense University of Madrid. Spain
    • National Center for Biotechnology. CNB-CSIC. Madrid, Spain.

    Associated Country : Spain


    Authors/Contributors : Pascual-Montano, A.
    Contact Email : pascual@fis.ucm.es
    Year : 2008
    Language : English

    Keywords : Centrosome / chemistry; Databases, Protein; Humans; Internet; Microtubule Proteins / chemistry / classification / genetics; Protein Isoforms / genetics; Protein Structure, Tertiary; Proteome / genetics