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  1. CPLA (View Publication)
    Full Name of the Resource : Compendium of Protein Lysine Acetylation
    Resource Category : Databases -> Protein Sequence Databases -> Protein properties

    Brief Description : As a reversible post-translational modification (PTM) discovered decades ago, protein lysine acetylation was known for its regulation of transcription through the modification of histones. Recent studies discovered that lysine acetylation targets broad substrates and especially plays an essential role in cellular metabolic regulation. Although acetylation is comparable with other major PTMs such as phosphorylation, an integrated resource still remains to be developed. In this work, we presented the CPLA (Compendium of Protein Lysine Acetylation, http://cpla.biocuckoo.org) database for lysine acetylated substrates with their sites. From the scientific literature, we manually collected 7,151 experimentally identified acetylation sites in 3,311 targets. Combined with protein-protein interaction (PPI) information, we systematically discovered a potential human lysine acetylation network (HLAN) among histone acetyltransferases (HATs), substrates and histone deacetylases (HDACs). In particular, there are 1,862 triplet relationships of HAT-substrate-HDAC retrieved from the HLAN, at least 13 of which were previously experimentally verified. The online services of CPLA database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0).
    Subject Area : Protein Lysine Acetylation


    Institute/s :
    Huazhong University of Science and Technology, Wuhan, China.
    Address of Institute/s :
    Department of Systems Biology, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
    Country : China

    Associated Institutes :

    • Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    • Department of Systems Biology, Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    • Department of Medicine, Molecular Oncology Group, McGill University Health Center and McGill Cancer Center, McGill University, Montr‚al, Quebec, H3A 1A1, Canada
    • School of Life Sciences, Sun Yat-sen University (SYSU), Guangzhou 510275, China.

    Associated Country : China; Canada


    Authors/Contributors : Yu Xue
    Contact Email : xueyu@mail.hust.edu.cn
    Year : 2010
    Language : English

    Keywords : Acetylation; Databases, Protein; Histone Acetyltransferases / metabolism; Histone Deacetylases / metabolism; Humans; Lysine / metabolism; Protein Processing, Post-Translational; Proteins / chemistry / metabolism; Systems Integration