Advance Search              Latest Recources





















Showing search results (1–2 of 2):

  1. CORG (View Publication)
    Full Name of the Resource : Comparative Regulatory Genomics: conserved non-coding blocks in vertebrate species
    Resource Category : Databases -> Nucleotide Sequence Databases -> Coding and coding DNA: genes, motifs and regulatory sites

    Brief Description : Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG - 'COmparative Regulatory Genomics' - database. The data were computed based on statistically significant local suboptimal alignments of 15Kb regions upstream of the translation start sites of, currently, 10,793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.
    Subject Area : Genomics


    Institute/s :
    Max-Planck-Institut for Entwicklungsbiologie
    Address of Institute/s :
    Max-Planck-Institut for Entwicklungsbiologie, Germany
    Country : Germany

    Associated Institutes :

    • Department of Evolutionary Biology, Max Planck Institute for Developmental Biology Spemannstrasse 35-37, 72076 T?bingen, Germany Department of Computational Biology, Max Planck Institute for Molecular Genetics Ihnestrasse 73, 14195 Berlin, Germany

    Associated Country : Germany


    Authors/Contributors : Dieterich, C.; Wang, H.; Rateitschak, K.; Luz, H.; Vingron, M.
    Contact Email : dieteric@molgen.mpg.de
    Year : 2006
    Language : English

    Keywords : Animals; Conserved Sequence; Databases, Nucleic Acid; Gene Expression Regulation; Genome, Human; Genomics; Humans; Internet; Mice; Regulatory Sequences, Nucleic Acid; Sequence Alignment / methods; Sequence Analysis, DNA / Methods; Transcription, Genetic


  2. CORG (View Publication)
    Full Name of the Resource : COmparative Regulatory Genomics: conserved non-coding blocks
    Resource Category : Databases -> Human and Other Vertebrate Genomes -> Model Organisms, Comparative Genomics

    Brief Description : Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG - 'COmparative Regulatory Genomics' - database. The data were computed based on statistically significant local suboptimal alignments of 15Kb regions upstream of the translation start sites of, currently, 10,793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.

    Institute/s :
    Max-Planck-Institute for Molecular Genetics, Ihnestra├če 73, 14195 Berlin, Germany
    Country : Germany

    Associated Institutes :

    • Department of Evolutionary Biology, Max Planck Institute for Developmental Biology Spemannstrasse 35-37, 72076 T├╝bingen, Germany
    • Department of Computational Biology, Max Planck Institute for Molecular Genetics Ihnestrasse 73, 14195 Berlin, Germany

    Associated Country : Germany


    Authors/Contributors : Dieterich, C.,
    Contact Email : christoph.dieterich@molgen.mpg.de
    Year : 2007
    Language : English

    Keywords : Animals; Cattle; Computer Graphics; DNA, Intergenic / chemistry; *Databases, Genetic; *Genes; *Genomics; Humans; Internet; Mice; *Promoter Regions, Genetic; Rats; Sequence Alignment; User-Computer Interface