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  1. CORG - A database for COmparative Regulatory Genomics (View Publication)
    Full Name of the Resource : Comparative Regulatory Genomics
    Resource Category : Databases -> RNA -> RNA Sequence, Structure and Functions

    Brief Description : Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG - 'COmparative Regulatory Genomics' - database. The data were computed based on statistically significant local suboptimal alignments of 15Kb regions upstream of the translation start sites of, currently, 10,793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service ( for query and interactive visualization of the conserved blocks and their annotation.
    Subject Area : Genomics

    Institute/s :
    Max-Planck-Institute for Molecular Genetic, Germany
    Address of Institute/s :
    Max-Planck-Institute for Molecular Genetics, Ihnestra├če 73, 14195 Berlin, Germany
    Country : Germany

    Associated Institutes :

    • Department of Evolutionary Biology, Max Planck Institute for Developmental Biology Spemannstrasse 35-37, 72076 T├╝bingen, Germany
    • Department of Computational Biology, Max Planck Institute for Molecular Genetics Ihnestrasse 73, 14195 Berlin, Germany

    Associated Country : Germany

    Authors/Contributors : C. Dieterich
    Contact Email :
    Year : 2006
    Language : English

    Keywords : Animals; Cattle; Computer Graphics; DNA, Intergenic / chemistry; Databases, Genetic; Genes; Genomics; Humans; Internet; Mice; Promoter Regions, Genetic; Rats; Sequence Alignment; User-Computer Interface