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  1. COG - Clusters of Orthologous Groups of proteins
    Resource Category : Databases -> Protein Sequence Databases -> Protein Classification

    Brief Description : The database of Clusters of Orthologous Groups of proteins (COGs) is an attempt on phylogenetic classification of the proteins encoded in complete genomes. Each COGs includes proteins that are inferred to be orthologs (direct evolutionary counterparts). The current release consists of 138,458 which form 4873 COGs and comprise 75% of the 185,505 proteins from 50 bacterial genomes, 13 archaeal genomes, and three genomes of unicellular eukaryotes, the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, and the microsporidian Encephalitozoon cuniculi (http://www.ncbi.nlm.nih.gov/COG). The COG database is updated periodically as new genomes become available. The COGs can be applied to the task of functional annotation of newly sequenced genomes by using the COGNITOR program, which is available on the COG front page.

    Institute/s :
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Address of Institute/s :
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Country : United States

    Associated Institutes :

    • National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

    Associated Country : USA


    Authors/Contributors : Roman L. Tatusov; Darren A. Natale; Igor V. Garkavtsev; Tatiana A. Tatusova; Uma T. Shankavaram; Bachoti S. Rao; Boris Kiryutin; Michael Y. Galperin; Natalie D. Fedorova; Eugene V. Koonin
    Contact Email : info@ncbi.nlm.nih.gov
    Year : 2000