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  1. AntiJen (View Publication)
    Full Name of the Resource : Quantitative binding data for peptides and proteins of immunological interest
    Resource Category : Databases -> Immunological Databases -> Immunological Databases

    Brief Description : AntiJen is a database system focused on the integration of kinetic, thermodynamic, functional, and cellular data within the context of immunology and vaccinology. Compared to its progenitor JenPep, the interface has been completely rewritten and redesigned and now offers a wider variety of search methods, including a nucleotide and a peptide BLAST search. In terms of data archived, AntiJen has a richer and more complete breadth, depth, and scope, and this has seen the database increase to over 31,000 entries. AntiJen provides the most complete and up-to-date dataset of its kind. While AntiJen v2.0 retains a focus on both T cell and B cell epitopes, its greatest novelty is the archiving of continuous quantitative data on a variety of immunological molecular interactions. This includes thermodynamic and kinetic measures of peptide binding to TAP and the Major Histocompatibility Complex (MHC), peptide-MHC complexes binding to T cell receptors, antibodies binding to protein antigens and general immunological protein-protein interactions. The database also contains quantitative specificity data from position-specific peptide libraries and biophysical data, in the form of diffusion co-efficients and cell surface copy numbers, on MHCs and other immunological molecules. The uses of AntiJen include the design of vaccines and diagnostics, such as tetramers, and other laboratory reagents, as well as helping parameterize the bioinformatic or mathematical in silico modeling of the immune system. The database is accessible from the URL: http://www.jenner.ac.uk/antijen.
    Subject Area : Immunology


    Institute/s :
    The Jenner Institute, University of Oxford, High Street, Compton, Berkshire, UK, RG20 7NN
    Address of Institute/s :
    The Jenner Institute, University of Oxford, High Street, Compton, Berkshire, UK, RG20 7NN
    Country : United Kingdom

    Associated Institutes :

    • The Jenner Institute, University of Oxford, High Street, Compton, Berkshire, UK, RG20 7NN

    Associated Country : United Kingdom


    Authors/Contributors : D.R. Flower
    Contact Email : darren.flower@jenner.ac.uk
    Year : 2005
    Language : English