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  1. AlzGene (View Publication)
    Full Name of the Resource : Candidate genes for Alzheimer disease
    Resource Category : Databases -> Human Genes and Diseases -> Gene, System or Disease-Specific Databases

    Brief Description : The AlzGene ( database aims to provide an unbiased, centralized, publicly available and regularly updated collection of genetic association studies performed on Alzheimer?s disease (AD) phenotypes. Data is collected following systematic searches of publicly available scientific literature databases, as well as the table of contents of journals in genetics, neurology and psychiatry. Extracted data will include characteristics of the investigated populations (e.g. origin and ethnicity, sample sizes, onset ages, gender distribution) as well as gene-specific results and genotyping details. Please note, that only studies published in peer reviewed journals are considered for inclusion into the database. The only exception from sampling all available genetic association studies are the e2/e3/e4 polymorphisms in APOE - the only established AD risk gene - for which only a subset of studies is included in AlzGene. The database can be searched either by gene/protein name or alias, as well as by chromosomal location. Summary overviews for each gene include population specific information, as well as study-specific information (e.g. genotype distribution and allele frequencies, links to the polymorphisms studied, etc.). Finally, a meta-analysis based on crude odds ratio (OR) estimates are calculated from the available case-control association data for each polymorphism with genotype data from at least three independent samples.

    Institute/s :
    Massachusetts General Hospital (Genetics and Aging Research Unit, Dept. of Neurology), Charlestown, MA, 02129, USA
    Alzheimer Research Forum, Waltham, MA 02452, USA

    Country : United States

    Authors/Contributors : Bertram L; Mullin K; McQueen M; Blacker D; Tanzi R.E; Kinoshita J; Noyes P; Knep C
    Contact Email :
    Year : 2007
    Language : English

    Keywords : Alzheimer Disease genetics; Apolipoprotein E4 genetics; Databases, Genetic; Genetic Heterogeneity; Genetic Linkage; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic