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  1. ASTD (View Publication)
    Full Name of the Resource : Alternative Splicing and Transcript Diversity database
    Resource Category : Databases -> Nucleotide Sequence Databases -> Gene Structure, Introns and Exons, Splice Sites

    Brief Description : The Alternative Splicing Database (ASD) Project aims to understand the mechanism of alternative splicing on a genome-wide scale by creating a database of alternative splice events and the resultant isoform splice patterns of genes from human, and other model species. At the moment three databases are available: AltSplice, AltExtron, and AEdb. AltSplice and AltExtron implement a computational pipeline that detects and characterise alternative intron/exons, alternative splice events, and isoform splice patterns. AltExtron considers gene entries from the EMBL database, while AltSplice considers gene entries from EnsEMBL. AEdb is the manually collected & curated (from literature) equivalent. AEdb comes in four forms, namely: AEdb-Sequence (sequence and properties of alternatively splice exons), AEdb-Function (data on functional aspects of alternative splicing), AEdb-motif (data and sequence of known splice regulatory motifs), and AEdb-minigene (a collection of known minigene constructs for alternative splice events). Other satellite databases generated by the members of the ASD consortium will be posted in due course. Currently, the computationally generated AltSplice database has been integrated with the manually curated database of AEdb. This integration adds the value of evidence to computationally predicted isoform splice events.
    Subject Area : Alternatice Gene Splicing


    Institute/s :
    EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, UK
    Address of Institute/s :
    EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Country : United Kingdom

    Associated Institutes :

    • European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UK
    • University of Erlangen, Institute for Biochemistry Fahrstrasse 17, 91054 Erlangen, Germany
    • Faculty of Medicine, Institute of Molecular Medicine, University of Lisbon 1649-028 Lisbon, Portugal

    Associated Country : United Kingdom; Germany; Portugal


    Authors/Contributors : Thangavel Alphonse Thanaraj
    Contact Email : thanaraj@ebi.ac.uk
    Year : 2005
    Language : English

    Keywords : Alternative Splicing/genetics; Animals; Database Management Systems; *Databases, Genetic; Humans; Information Storage and Retrieval/methods; Mice; Rats; Reproducibility of Results; Software; User-Computer Interface