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  1. ACTIVITY (View Publication)
    Full Name of the Resource : Functional DNA/RNA site activity
    Resource Category : Databases -> Nucleotide Sequence Databases -> Transcriptional regulator sites and transcription factors

    Brief Description : ACTIVITY, a database on DNA site sequences with known activity magnitudes, measurement systems and sequence-activity relationships under fixed experimental conditions is additionally adapted to applications to the phylogenetic footprints of known sites. To this aim, we have created three resources, ACTIVITY_Reports, ACTIVITY_Tuning, and TFsite_Annotations. For a given site with known sequence-activity relationships, the first database ACTIVITY_Reports accumulates the quantitative data on the impact of the site surrounding, which allows for correct recognition of this site. From this way characterized site-surrounding relationships, the Java applet aimed at precise analysis of phylogenetic footprints of only this known site is automatically generated and stored within the knowledge base ACTIVITY_Tuning. Next, the resulting database TFsite_Annotations documents the Java applet results obtained in the cases of only putative sites of the same type and the same location within the same regulatory region of the homologous gene. The resources enriching the current ACTIVITY release are available at URL=http://util.bionet.nsc.ru/databases/activity.html.
    Subject Area : DNA Sequence Activity


    Institute/s :
    Institute of Cytology and Genetics, 10 Lavrentyev Avenue, Novosibirsk,Russia.
    Address of Institute/s :
    Institute of Cytology and Genetics, 10 Lavrentyev Avenue, Novosibirsk, 630090, Russia.
    Country : Russia


    Authors/Contributors : Ponomarenko, J. V.
    Contact Email : jpon@bionet.nsc.ru
    Year : 2001
    Language : English

    Keywords : Binding Sites; DNA / genetics / metabolism; Databases, Factual; Gene Expression Regulation; Internet; Protein Binding; RNA / genetics/metabolism