Advance Search              Latest Recources





















Showing search results (1–1 of 1):

  1. ABCdb (View Publication)
    Full Name of the Resource : Archaeal and bacterial ABC transporter database
    Resource Category : Databases -> Protein Sequence Databases -> Databases of Individual Protein Families

    Brief Description : ABCdb is a public resource devoted to the ABC transporters encoded by completely sequenced prokaryotic genomes. The ABC proteins are involved in a wide variety of physiological processes in Archaea, Bacteria and Eucaryota where they are encoded by large families of paralogous genes. The majority of ABC domains energize the transport of compounds across membranes. In bacteria, ABC transporters are involved in the uptake of a wide variety of molecules, as well as in mechanisms of virulence and antibiotic resistance. In eukaryotes, most of them are involved in drug resistance and in human cell, many are associated with diseases. Sequence analysis reveals that members of the ABC superfamily can be organized into sub-families, and suggests that they have diverged from common ancestral forms. A typical ABC transporter system is composed of an assembly of protein domains that serve different functions: i) two Nucleotide Binding Domains (NBD) that energize transport via ATP hydrolysis, ii) two Membrane Spanning Domains (MSD) that act as a membrane channel for the substrate, and iii) for the importer, a Solute Binding Protein (SBP) that confers substrates specificity on the transporter. The different partners of an ABC system are generally encoded by neighboring genes. ABCdb has been implemented in the ACeDB format, a database system developed by Jean Thierry-Mieg and Richard Durbin.
    Subject Area : Prokaryotic Genomes, Protein


    Institute/s :
    Universite Paul Sabatier, CNRS-LMGM - UMR 5100, 118 route de Narbonne, 31062 Toulouse cedex 9, France
    Address of Institute/s :
    Universite Paul Sabatier, CNRS-LMGM - UMR 5100, 118 route de Narbonne, 31062 Toulouse cedex 9, France
    Country : France

    Associated Institutes :

    • Universite Paul Sabatier, CNRS-LMGM - UMR 5100, 118 route de Narbonne, 31062 Toulouse cedex 9, France

    Associated Country : France


    Authors/Contributors : Gwennaele Fichant; Marie-Jeanne Basse; Yves Quentin
    Contact Email : quentin@ibcg.biotoul.fr
    Year : 2006
    Language : English

    Keywords : ATP-Binding Cassette Transporters; Computational Biology methods; Databases, Genetic; Genes, Archaeal; Genes, Bacterial; Genome, Archaeal genetics; Genome, Bacterial genetics